Flavokavain B from the rhizome of Alpinia mutica Roxb
نویسندگان
چکیده
THE TITLE COMPOUND [SYSTEMATIC NAME: (E)-1-(2-hydroxy-4,6-dimethoxyphenyl)-3-phenylprop-2-en-1-one], C(17)H(16)O(4), has an aromatic ring at both ends of the -CH= CH-C(=O)- fragment with the -CH=CH- bond in a trans configuration. The phenyl ring is nearly coplanar with this fragment [dihedral angle 4.8 (3) °] as is the hy-droxy-ldimeth-oxy-lphenyl unit [dihedral angle 6.3 (3) °]. The hy-droxy group is the donor in an intra-molecular hydrogen bond to the double-bonded O atom.
منابع مشابه
Essential Oil Composition and Antimicrobial Activities of Two Closely Related Species, Alpinia mutica Roxb. and Alpinia latilabris Ridl., from Peninsular Malaysia
The essential oils obtained by hydrodistillation of the unripe and ripe fruits of Alpinia mutica Roxb. and Alpinia latilabris Ridl. were analysed by capillary GC and GC-MS. The oils were principally monoterpenic in nature. The unripe and ripe fruit oils of A. mutica were characterized by camphor (21.0% and 15.8%), camphene (16.6% and 10.2%), β-pinene (8.6% and 13.5%), and trans,trans-farnesol (...
متن کاملCorrection: Crude Extracts, Flavokawain B and Alpinetin Compounds from the Rhizome of Alpinia mutica Induce Cell Death via UCK2 Enzyme Inhibition and in Turn Reduce 18S rRNA Biosynthesis in HT-29 Cells
[This corrects the article DOI: 10.1371/journal.pone.0170233.].
متن کاملCrude Extracts, Flavokawain B and Alpinetin Compounds from the Rhizome of Alpinia mutica Induce Cell Death via UCK2 Enzyme Inhibition and in Turn Reduce 18S rRNA Biosynthesis in HT-29 Cells
Uridine-cytidine kinase 2 is an enzyme that is overexpressed in abnormal cell growth and its implication is considered a hallmark of cancer. Due to the selective expression of UCK2 in cancer cells, a selective inhibition of this key enzyme necessitates the discovery of its potential inhibitors for cancer chemotherapy. The present study was carried out to demonstrate the potentials of natural ph...
متن کاملIn Silico Discovery of Potential Uridine-Cytidine Kinase 2 Inhibitors from the Rhizome of Alpinia mutica.
Uridine-cytidine kinase 2 is implicated in uncontrolled proliferation of abnormal cells and it is a hallmark of cancer, therefore, there is need for effective inhibitors of this key enzyme. In this study, we employed the used of in silico studies to find effective UCK2 inhibitors of natural origin using bioinformatics tools. An in vitro kinase assay was established by measuring the amount of AD...
متن کاملAntioxidant properties of crude and fractionated extracts of Alpinia mutica rhizomes and their total phenolic content
In the present study, the antioxidant potential of the crude methanol and its fractionated extracts (hexane, ethyl acetate and water) of the rhizomes of Alpinia mutica was investigated, employing four different assays. The antioxidant assays used were 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging, β-carotene bleaching, superoxide dismutase (SOD) and the reducing power assays while th...
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